Parallel RNA Interference Screens Identify EGFR Activation as an Escape Mechanism in FGFR3-Mutant Cancer
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منابع مشابه
Parallel RNA interference screens identify EGFR activation as an escape mechanism in FGFR3-mutant cancer.
UNLABELLED Activation of fibroblast growth factor receptors (FGFR) is a common oncogenic event. Little is known about the determinants of sensitivity to FGFR inhibition and how these may vary between different oncogenic FGFRs. Using parallel RNA interference (RNAi) genetic screens, we show that the EGF receptor (EGFR) limits sensitivity to FGFR inhibition in FGFR3-mutant and -translocated cell ...
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ژورنال
عنوان ژورنال: Cancer Discovery
سال: 2013
ISSN: 2159-8274,2159-8290
DOI: 10.1158/2159-8290.cd-12-0569